Equation of Hekal for Adjusting the Serum PSA for Age and Body Mass Index (BMI)

 

Patient selection: obese male in 50's or 60's with a high normal or borderline elevated PSA

 

Parameters:

(1) serum PSA in ng/mL

(2) age in years

(3) body mass index in kg per square meter

 

adjusted PSA in ng/mL =

= (PSA) * (age in years) / (BMI)

 

where:

• The adjusted units are in ng/mL, without inclusion of the years or BMI.

 

Performance:

• The adjusted score supposedly helps to identify obese males in their 50's and 60's who should undergo prostate biopsy.

• The AUC of the ROC curve for benign cases was 0.59 and for malignant cases 0.41. These values are not indicative of a useful test.