The dosing interval for an oral drug regimen can be determined from the desired plasma concentrations and the drug's kinetic properties.
Parameters:
(1) peak plasma drug concentration in mg/L
(2) minimum plasma drug concentration in mg/L
(3) half-life of the drug in hours
(4) fraction of the drug that is absorbed
(5) elimination rate constant
maximum dosing interval in hours =
= LN((peak drug concentration) / (minimum drug concentration)) / (elimination rate constant) =
= 1.44 * (half-life) * LN((peak drug concentration) / (minimum drug concentration))
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Specialty: Toxicology, Emergency Medicine, Critical Care
ICD-10: ,
