Dosing an Infusion of Abbokinase Brand Urokinase for a Patient with Pulmonary Embolism

 

Parameters:

(1) body weight of patient

(2) number of vials of Abbokinase (each containing 250,000 IU, reconstituted to 5 mL sterile water)

(3) amount of diluent (0.9% saline) to add

Body Weight of Patient in Pounds	Number of Vials to Administer
81 - 90	9
91 - 100	10
101 - 110	11
111 - 120	12
121 - 130	13
131 - 140	14
141 - 150	15
151 - 160	16
161 - 170	17
171 - 180	18
181 - 190	19
191 - 200	20
201 - 210	21
211 - 220	22
221 - 230	23
231 - 240	24
241 - 250	25

 

total dose from combined vials in IU =

= (250,000 * (number of vials))

 

total volume after combining vials in mL =

= (5 * (number of vials combined))

 

standard infusion volume = 195 mL

 

amount of diluent to add to the combined volumes of all the vials in mL =

= 195 - (5 * (number of vials))

 

The loading dose is an infusion of 15 mL given over 10 minutes using an infusion pump set at 90 mL per hour. This delivers approximately 2,000 IU per pound body weight (4,400 IU per kilogram).

 

The remainder of the infusion is given over 12 hours at a rate of 15 mL per hour. This delivers approximately 2,000 IU per pound per hour (4,400 IU per kilogram per hour).

 

195 mL = (15 mL for the loading dose) + (15 mL * 12 hours)

 

After completing the infusion, residual infusate in the infusion tubing should be flushed using 0.9% normal saline.