Hemorrhagic disease of the newborn (HDNB) needs to be distinguished from other causes of neonatal or infantile bleeding.
Hereditary coagulation factor defects:
(1) hemophilia A or B (Factor 8 or 9 deficiency)
(2) von Willebrand’s disease
Acquired coagulation factor defects:
(1) coumarin or heparin exposure (accidental, intentional)
(2) liver disease
Thrombocytopenia:
(1) hereditary platelet defects
(2) immune thrombocytopenic purpura (ITP)
(3) neonatal isoimmune thrombocytopenia
(4) congenital leukemia
(5) bone marrow hypoplasia or aplasia
Multifactorial:
(1) disseminated intravascular coagulation (DIC)
(2) infection or sepsis
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Specialty: Hematology Oncology, Clinical Laboratory, Nutrition, Pharmacology, clinical, Pedatrics
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