Drug-induced phospholipidosis (DIP, cationic amphiphilic drug-induced phospholipidosis) is associated with a number of diagnostic features.
Diagnostic features:
(1) There is an accumulation of phospholipids within cells.
(2) The phospholipids are present as membranous lamellar bodies derived from lysosomes.
(3) The person is taking a drug with cationic amphiphilic features.
(4) The drug accumulates in association with the phospholipids.
(5) The features reverse upon discontinuation of the implication drug.
Theories for DIP:
(1) The inciting drug binds to the phospholipids and the combination becomes resistant to degradation by phospholipases.
(2) The inciting drug directly inhibits the phospholipase.
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Specialty: Toxicology, Emergency Medicine, Critical Care
