Description

De Letter et al describe the clinical diagnosis of critical illness polyneuropathy and myopathy (CIPNM) for patients in the Intensive Care Unit (ICU) . The authors are from three hospitals in the Netherlands.


 

NOTE: The clinical examination for determining muscle and tendon status are described in the previous section.

 

Exclusion criteria: Neuromuscular blocking agents within past 3 days.

 

Criteria - both of the following:

(1) both clinical findings on 2 or more consecutive assessments

(2) electrophysiologic evidence of axonal polyneuropathy

 

Clinical Finding

Cooperative Patient

Uncooperative Patient

motor sumscore

0 - 25 (< 26; out of 30)

0 - 7 (< 8; out of 10)

tendon reflexes

decreased or absent

decreased or absent

 

Electrophysiologic findings:

(1) findings in ulnar nerve

(1a) distal compound muscle action potential (CMAP) absent or < 4.2 mV

(1b) no evidence of entrapment at the elbow

(1c) no evidence of demyelination (ratio of proximal CMAP area to distal CMAP area > 0.89)

(2) findings in peroneal nerve

(2a) distal compound muscle action potential (CMAP) absent or < 2.6 mV

(2b) no evidence of entrapment at the fibular head

(2c) no evidence of demyelination (ratio of proximal CMAP area to distal CMAP area > 0.89)

(3) spontaneous activity at rest (fibrillations and/or positive waves) in >= 2 examined muscles

 

Electrophysiologic criteria: 2 or more of the findings present (1 and 2, 1 and 3, 2 and 3)

 


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