Description

Hilton-Jones et al reported modified criteria for the diagnosis of sporadic inclusion body myositis (IBM). This was reported at a workshop in London during June, 2008.


Parameters:

(1) duration of weakness in months

(2) age of the patient in years

(3) pattern of weakness in the upper and lower extremities

(3a) finger extension is weaker than shoulder abduction (associated with atrophy of the forearm muscles)

(3b) knee extrension is weaker than hip flexion (associated with atrophy of the quadriceps muscles)

(4) histologic features

(4a) mononuclear cells infiltrating non-necrotic endomysial fibers

(4b) rimmed vacuoles

(4c) either 15 to 18 nm filaments (causing eosinophilic inclusions) and/or amyloid deposits within myocytes

 

Duration

Age

Pattern

Histologic Features

Diagnosis

> 12 months

> 35 years

both upper and lower extremities

present

definite

> 12 months

> 35 years

upper or lower extremities

present

possible

NA

NA

NA

present

pathologic

 


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