Sevelamer hydrochloride (Renagel, Genzyme) is a phosphate binding agent that can reduce serum phosphate levels in patients with end-stage renal disease.
Formulations:
(1) 400 mg tablets
(2) 403 mg capsules
(3) 800 mg tablets
Initiating Therapy
Serum Phosphorus Level
Dose 400 mg tablets or capsules
Dose 800 mg tablets
>= 9.0 mg/dL
4 tablets or capsules 3 times daily with meals
2 tablets 3 times daily with meals
>= 7.5 and < 9.0 mg/dL
3 tablets or capsules 3 times daily with meals
2 tablets 3 times daily with meals
> 6.0 and < 7.5 mg/dL
2 tablets or capsules 3 times daily with meals
1 tablet 3 times daily with meals
Serum Phosphorus Level
Dosage Adjustment
< 3.5 mg/dL
decrease one 400 mg tablet or capsule per meal
3.5 to 6.0 mg/dL
maintain current dose
> 6.0 mg/dL
increase one 400 mg tablet or capsule per meal at 2 week intervals
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