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Daily Dose and Other Risk Factors of Lodise et al for Vancomycin-Associated Nephrotoxicity

Description

Lodise et al identified risk factors for nephrotoxicity in a patient being treated with vancomycin. These factors can help to identify a patient who may benefit from interventions to reduce the risk. The authors are from Albany College of Pharmacy, Ordway Research Institute (Albany), and Albany Medical Center.


 

Parameters:

(1) daily vancomycin dose in grams

(2) body weight in kilograms

(3) estimated creatinine clearance in mL per minute

(4) hospital location

Parameter

Finding

Points

daily vancomycin dose

< 4 grams

0

 

>= 4 grams

1

body weight

< 101.4 kg

0

 

>= 101.4 kg

1

estimated creatinine clearance

> 86.6 mL per minute

0

 

<= 86.6 mL per minute

1

hospital location

ICU

1

 

other

0

 

total number of risk factors =

= SUM(points for all 4 risk factors)

 

Interpretation:

• minimum number of risk factors: 0

• maximum number of risk factors: 4

• The greater the number of risk factors the greater the risk for nephrotoxicity.

 


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