The major criterion is the appearance of the fundus:
(1) multiple small depigmented flecks (birdshot spots, that mimic the spread of birdshot from a shotgun)
(2) these radiate from the margins of the optic nerve head towards the periphery
(3) bilateral and symmetrical
Other findings in the fundus:
(1) mild to severe vitritis
(2) retinal vasculopathy with cystoid macular edema
(3) involvement of the optic nerve head
Clinical findings (>= 2 should be present):
(1) blurred vision
(2) floaters
(3) night blindness
(4) distorted vision
(5) photopsia
(6) irritation
(7) ocular pain
(8) decreased visual acuity
Most patients have HLA A29.
Complications:
(1) epiretinal membranes
(2) retinal neovascularization
(3) subretinal neovascular membranes
(4) cellophane maculopathy
(5) recurrent vitreous hemorrhage
(6) optic atrophy
(7) retinal detachment
