Norden et al reported quantitative criteria for tubular proteinuria. The authors are from Chase Farm Hospital, State University of New York (Syracuse), Erasme Hospital (Brussels), John Radcliffe Hospital, and University College London.
Specimen: urine without evidence of hematuria
Parameters:
(1) urine retinol binding protein (RBP) in mg/L
(2) urine creatinine in mmol/L
(3) urine albumin in mg/L
ratio of urine RBP to creatinine in mg/mmol =
= (urine RBP) / (urine creatinine)
ratio of urine albumin to creatinine in mg/mmol =
= (urine albumin) / (urine creatinine)
Criteria for tubular proteinuria – both of the following:
(1) urinary RBP to creatinine ratio > 0.017 mg/mmol
(2) urinary albumin to creatinine ratio < (10 * (urinary RBP to creatinine ratio)) + 2
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