Inheritance: autosomal dominant
Major criteria:
(1) variable skin involvement (hyperextensible skin and/or smooth, velvety skin)
(2) generalized joint hypermobility involving small and large joints
Minor criteria:
(1) recurring joint dislocations
(2) chronic joint or limb pain: Musculoskeletal pain shows an early onset and may be disabling
(3) positive family history
Other findings:
(1) dilatation and/or rupture of the ascending aorta
(2) scoliosis, pes planus and other musculoskeletal changes may be found.
Distinction from the classical type:
(1) Patients with the hypermobility type have normal scarring. The presence of atrophic scars suggests the classical type.
(2) Molluscoid pseudotumors are absent in the hypermobility type.
