Creatinine Velocity in a Child with Posterior Urethral Valves (PUV)

Description

Coleman et al used the creatinine velocity to evaluate a child with posterior urethral valve (PUV). This can help to identify a child at increased risk for chronic renal insufficiency. The authors are from the Children’s Hospital in Birmingham, England.

Patient selection: infant with posterior urethral valve, treated within 30 days of birth

Outcome: chronic renal insufficiency

Parameters:

(1) daily serum creatinine for the first 5 days after initial drainage, in µmol/L

creatinine velocity =

= SLOPE(dataset) in µmol/L/dau

Creatinine Velocity	Interpretation	Risk of Renal Insufficiency
< -3	falling	low
-3 to 3	neither rising nor falling (plateau)	intermediate
> 3	rising	high

Performance:

• The sensitivity was 78% and specificity 82%.

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Creatinine Velocity in a Child with Posterior Urethral Valves (PUV)

Description

Specialty