Creatinine clearance overestimates the GFR. The overestimation is greater in renal disease and when "true" methods are used.
Renal Status
Cr Cl mL/min
normal (males)
90 - 130
normal (females)
80 - 125
slight impairment
52 - 62.5
mild impairment
42 - 52
moderate impairment
28 - 42
severe impairment
< 28
anuric
0
from page 655, Wallach (1996); Newkirk (1978)
normal
> 80
50 - 79
10 - 49
< 10
from: Table 1, Jackson and McLeod (1974)
renal function (as % normal)
turnover time (hours) of creatinine
half-life (hours) of creatinine
100
6
4
50
12
8
33
18
25
24
17
20
30
21
10
60
42
from Table 23-2, page 432, Rowland (1995)
This data can be represent:
half-life of serum creatinine =
= (426.4 / (percent normal renal function)) - 0.6447
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Specialty: Nephrology, Clinical Laboratory
