Description

A Radioallergoabsorbent test (RAST) can be helpful in identifying IgE antibody directed against a specific allergen. However, there are times that it should not be performed because of cost inefficiency, lack of indications or the possibility of misleading results.


 

Conditions associated with a false positive reaction:

(1) recent administration of a radioisotope <absolute contraindication>

(2) very high serum IgE levels (> 3,000 kIU/L)

 

Conditions associated with a false negative reaction:

(1) very low serum IgE levels (< 10 kIU/L) <relative contraindication>

 

No evidence for an IgE-mediated allergic reaction:

(1) investigation of a reaction that is not IgE-mediated

(2) multiple skin tests that have all been negative

 

The presence of a mild IgE-mediated allergy that is easily managed:

(1) presence of only minor symptoms

(2) symptoms that are well-managed by avoidance and simple medications

(3) adequate response to immunotherapy

 


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