Angioedema needs to be distinguished from other conditions that can cause localized or generalized swellings.
Allergic reactions:
(1) contact dermatitis
(2) poison ivy, poison oak or other Rhus-containing plants
Immune disorders:
(1) acquired C1-inhibitor deficiency syndrome
(2) autoantibodies (hypocomplementemic urticarial vasculitis syndrome)
(3) Crohn's disease (affecting the lower lip)
(4) tumor necrosis factor receptor-associated periodic syndrome (TRAPS)
(5) Weber-Christian disease (febrile, nonsuppurative panniculitis)
Edema:
(1) acute idiopathic scrotal edema
(2) dependent edema
(3) superior vena cava syndrome
(4) severe protein malnutrition
(5) Clarkson's syndrome (idiopathic capillary leak syndrome)
Infiltrative disorders:
(1) systemic amyloidois
(2) scleromyxedema
(3) thyroid orbitopathy in Grave's disease
(4) Well's disease (skin plaques with eosinophilia)
(5) Shulman's syndrome (eosinophilic fasciitis)
(6) Melkersson-Rosenthal syndrome (noncaseating granulomas in the lips)
Infections:
(1) cellulitis
(2) parasite infections (trichinosis, Loa Loa, trypanosomiasis)
(3) viral infection
Physical injury:
(1) trauma
(2) thermal burns
(3) chemical burns
Miscellaneous:
(1) blepharochalsis (relaxation of eyelid skin)
Specialty: Immunology/Rheumatology
ICD-10: ,