A woman with essential thrombocythemia (ET) may encounter a number of problems during pregnancy. Only 50 to 60% of pregnancies will result in a liveborn infant.
Risk factors for complications:
(1) JAK2 mutation JAK2(617V>F)
(2) history of previously affected pregnancy (recurrent)
(3) failure to treat the mother with interferon-alpha throughout the pregnancy
Fetal complications:
(1) fetal wastage (first or second trimester abortion, third trimester stillbirth)
(2) intrauterine growth retardation
(3) pre-term delivery
Maternal complications:
(1) pre-eclampsia or eclampsia
(2) arterial hypertension (without eclampsia)
(3) post-partum bleeding
Placental lesions:
(1) infarcts
(2) abruptio placenta
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