Topical compounds containing mercury:
(1) skin lightening creme (inhibits tyrosinase, which produces melanin)
(2) calomel (as a treatment for syphilis)
(3) ointment of yellow mercuric oxide or ammoniated mercury for psoriasis
(4) topical ointments containing metallic mercury
(5) soaps
Absorption is affected by:
(1) concentration of the mercury salt
(2) surface area covered
(3) breaks in skin continuity (eczema, impetigo, psoriasis)
(4) duration of application
Complications:
(1) contact sensitivity
(2) anaphylaxis
(3) renal toxicity with proteinuria, including the nephrotic syndrome
(4) skin hyperpigmentation
