Common Toxicity Criteria (CTC) for Musculoskeletal Adverse Events Associated with Cancer Therapy

Description

The Common Toxicity Criteria (CTC) define adverse events following cancer therapy. It was designed for use in clinical trials of different therapeutic regimens.

Types of musculoskeletal adverse events:

(1) arthritis (pain with inflammation, erythema and/or joint swelling)

(2) muscle weakness (not due to neuropathy)

(3) myositis (inflammation and damage of muscle with elevated CPK)

(4) osteonecrosis (avascular necrosis)

(5) other

NOTES:

(1) Arthralgia (joint pain without signs of inflammation) is graded in the "Pain" category.

(2) Myalgia is graded in the "Pain" category.

Grade 0: normal or no change

Parameter	Finding	Grade
arthritis	none	0
	mild pain; does not interfere with function	1
	pain interferes with function but not ADL	2
	pain interferes with function and ADL	3
	disabling	4
muscle weakness	none	0
	asymptomatic with weakness on physical exam	1
	symptomatic; interferes with function but not ADL	2
	symptomatic; interferes with ADL	3
	bedridden or disabling	4
myositis	none	0
	mild pain; does not interfere with function	1
	pain interferes with function but not ADL	2
	pain interferes with function and ADL	3
	bedridden or disabling	4
osteonecrosis	none	0
	asymptomatic and detected by imaging only	1
	symptomatic; interferes with function but not ADL	2
	symptomatic; interferes with ADL	3
	bedridden or disabling	4
other	none	0
	mild	1
	moderate	2
	severe	3
	life-threatening or disabling	4

where:

• ADL = activities of daily living

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Common Toxicity Criteria (CTC) for Musculoskeletal Adverse Events Associated with Cancer Therapy

Description

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