Settin et al used a clinical score to identify patients who may have Familial Mediterranean Fever (FMF). This can help identify patients who may benefit from mutation analysis. The authors are Mansoura University and Al-Azhar University in Egypt.
Parameters:
(1) family history
(2) consanguinity
(3) duration of each attack in days
(4) frequency of attacks
(5) fever in °C
(6) abdominal pain
(7) joint involvement
(8) chest pain
(9) myalgia
(10) history of operations
Parameter |
Finding |
Points |
---|---|---|
family history |
negative |
1 |
|
positive |
2 |
consanguinity |
absent |
1 |
|
present |
2 |
duration of each attack |
< 3 days |
1 |
|
3 to 5 days |
2 |
|
> 5 days |
3 |
frequency of attacks |
< 10 per year |
1 |
|
10 to 30 per year |
2 |
|
> 30 per year |
3 |
fever |
none |
1 |
|
<= 39°C |
2 |
|
> 39°C |
3 |
abdominal pain |
negative |
1 |
|
moderate (does not interfere with activities) |
2 |
|
severe (interferes with activities) |
3 |
joint involvement |
none |
1 |
|
arthralgias |
2 |
|
arthritis |
3 |
chest pain |
none |
1 |
|
moderate (does not interfere with activities) |
2 |
|
severe (interferes with activities) |
3 |
myalgia |
none |
1 |
|
moderate (does not interfere with activities) |
2 |
|
severe (interferes with activities) |
3 |
history of operation |
negative |
1 |
|
positive |
2 |
total score =
= SUM(points for all 10 parameters)
Interpretation:
• minimum score: 10
• maximum score: 27
• The higher the score the more likely the diagnosis of FMF.
• The diagnosis can be confirmed by demonstration of mutations in the MEFV gene on the short arm of chromosome 16 (using amplification refractory mutation system based on the polymerase chain reaction, or ARMS-PCR).
Total Score |
Diagnosis of FMF |
---|---|
< 15 |
unlikely |
15 to 20 |
probable |
> 20 |
definite |
Purpose: To evaluate a patient for Familial Mediterranean Fever (FMF) using the clinical score of Settin et al.
Specialty: Immunology/Rheumatology, Genetics, Infectious Diseases, Pedatrics
Objective: clinical diagnosis, including family history for genetics
ICD-10: E85,