The Ovarian Hyperstimulation Syndrome (OHSS) is a complication of exogenous gonadotropin therapy given to induce ovulation. A similar reaction from endogenous gonadotropins is hyperrectio luteinalis. The syndrome can be clinically graded based on the signs and symptoms.
Symptoms
Other Findings
Clinical Grade
nausea, abdominal discomfort
ovarian enlargement (5 -12 cm) with multiple follicles
mild
vomiting and/or diarrhea; abdominal distension
mild ascites present
moderate
thromboembolism; impaired renal function; leg or vulval edema
moderate to marked ascites and/or hydrothorax; hepatic dysfunction
severe
where:
• Thromboembolism is due to hypercoagulability and may be arterial or venous. It may be due to high estrogen levels.
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