Deficiency of Factor XIII is rare and results in a bleeding disorder with a number of findings that may suggest the diagnosis.
Inheritance of hereditary deficiency: autosomal recessive
Clinical findings:
(1) bleeding from the umbilicus in the neonatal period
(2) delayed separation of the umbilical cord
(3) delayed bleeding 12-36 hours after trauma
(4) poor wound healing
(5) unexplained and repeated intracranial hemorrhage
(6) hemarthrosis
(7) recurrent fetal loss in females
Laboratory findings:
(1) normal PT and PTT
(2) abnormal clot solubility in 5 M urea or a weak organic acid
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Specialty: Hematology Oncology, Clinical Laboratory
ICD-10: ,
