Sen et al listed clinical findings that may occur following accidental intra-arterial injection of a drug. The authors are from the Mayo Clinic.
Early clinical findings (immediate or during first 24 hours):
(1) pain
(2) flushing
(3) tingling, burning, numbness and paresthesias
(4) muscle weakness and cramping
(5) decreased capillary refill
(6) skin mottling
(7) phlebitis and arterial thrombosis
(8) pulselessness
where:
• Patients receiving an intravenous infusion of propofol may complain of pain and burning, so some of the findings listed above may be nonspecific.
Delayed findings (48 hours or more):
(1) compartment syndrome
(2) rhabdomyolysis
(3) permanent contractions
(4) ischemic necrosis
(5) gangrene
(6) autoamputation
(7) disability
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Specialty: Toxicology, Emergency Medicine, Critical Care
ICD-10: ,
