NOTE: This syndrome shows overlap with Binswanger syndrome of vascular dementia.
Clinical findings are variable, depending on the pattern of infarction:
(1) Parkinson like syndrome but with resting tremor usually absent.
(2) abnormal gait, especially if there is a wide-based shuffling gait
(3) dementia
(4) pseudobulbar findings
(5) freezing
(6) urinary incontinence
(7) pyramidal signs
(8) variable postural tremor
(9) variable response to levodopa or other dopaminergic therapy (most respond poorly, while others show some response)
(10) variable history of stroke
Imaging findings:
(1) extensive small-vessel disease
(2) multiple infarcts in the basal ganglia and subcortical white matter
