Findings in the head and neck:
(1) high arched palate
(2) hearing loss
(3) micrognathia
(4) webbed neck
(5) low set, posteriorly rotated ears
(6) low posterior hairline
(7) bushy eyebrows
(8) ptosis
(9) strabismus
Musculoskeletal changes:
(1) short stature
(2) shield chest with widely spaced nipples
(3) scoliosis
Visceral changes:
(1) congenital heart defect (coarctation of the aorta, bicuspid aortic valve, aortic atresia)
(2) renal anomaly (horseshoe, duplications, vascular abnormalities, etc.)
Changes in the hands and feet
(1) puffy hands and/or feet (associated with lymphedema)
(2) cubitus valgus
(3) short fourth metacarpal
(4) nail dysplasia (hyperconvex, narrow, inserted at a sharp angle)
Gonadal:
(1) absent, delayed or arrested puberty
(2) infertility
Endocrine:
(1) insulin resistance
(2) type II diabetes mellitus
(3) hypothyroidism
