Description

Pseudotumor cerebri (idiopathic intracranial hypertension) is a clinical syndrome associated with intracranial hypertension not caused by hydrocephalus or a mass lesion.


 

Clinical findings:

(1) diffuse headache, which may be worse at night or in the morning

(2) papilledema

(3) variable visual field loss

(4) palsy of cranial nerve VI

(5) normal neuroimaging studies (no evidence hydrocephalus or mass lesions)

(6) normal CSF analysis (low or normal protein, normal glucose, normal cellularity)

(7) increased CSF opening pressure

 

Idiopathic cases usually involve obese young females with menstrual irregularities.

 

Secondary causes:

(1) drugs (lithium, tetracycline, steroids, sulfonamides, nalidixic acid, tamoxifen, others)

(2) large doses of vitamin A

(3) venous thrombosis (thrombosis of the internal jugular vein associated with hyperalimentation, sinus thrombosis)

 


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