Neurolymphomatosis refers to infiltration of one or more nerves by malignant lymphoma cells.
Clinical findings:
(1) The patient usually has widespread malignant lymphoma.
(2) The patient may have a cranial or spinal sensorimotor polyneuropathy which may be painful or painless.
(3) Other causes of neuropathy are excluded.
Electromyography shows a polyneuropathy with low amplitude motor action potentials.
A nerve biopsy shows diffuse infiltration of the nerve by lymphoma cells. A muscle biopsy shows neurogenic muscle atrophy.
Differential diagnosis:
(1) peripheral neuropathy associated with chemotherapy
(2) leptomeningeal lymphomatosis
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Specialty: Hematology Oncology
ICD-10: ,
