Clinical findings:
(1) right upper quadrant pain
(2) migratory panniculitis, with foci lasting 2-3 weeks
(2a) large pruritic or painful plaques
(2b) deep-seated nodules
(3) cutaneous tracks of larva migrans (sinuous, erythematous, pruritic chords)
Complications
(1) eosinophilic myeloencephalitis, which follows penetration of larvae into the CNS: headache, altered level of consciousness, sensory impairment, paralysis, seizures, etc
(2) ocular invasion
(3) mediastinal involvement
Laboratory findings:
(1) variable peripheral eosinophilia
(2) positive immunoblot test for antibodies
(3) With CNS involvement there may be eosinophils in the CSF with blood or xanthochromia
Histologic findings in a biopsy of a lesion:
(1) eosinophilic panniculitis (eosinophils involving subcutaneous fat). A larva may be difficult to locate since they are relatively small.
