Familial Hyperaldosteronism Type 2 (FH2) is a rare, hereditary cause of hyperaldosteronism.
Genetic Locus: 7p22
Genes Affected: uncertain
Gene Mutation: uncertain
Inheritance: autosomal dominant
A patient may have bilateral adrenocortical hyperplasia and/or adrenocortical adenomas.
Clinical features:
(1) hypertension
(2) failure of glucocorticoid therapy (dexamethasone, other) to control the hypertension
Laboratory findings:
(1) elevated plasma aldosterone levels
(2) low plasma renin activity
(3) absence of the chimeric gene associated with FH1
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Specialty: Endocrinology, Clinical Laboratory
