The external genitalia of patients with Androgen Insensitivity Syndrome (AIS) may range from phenotypically male to female and anywhere in-between.
Clinical Appearance |
Grade |
normal masculinization |
1 |
male phenotype with mild defect (isolated hypospadia) |
2 |
male phenotype with severe defect (small penis, perineoscrotal hypospadias, bifid scrotum, and/or cryptorchidism) |
3 |
severe genital ambiguity (phallus intermediate between clitoris and penis, labioscrotal folds, single perineal orifice) |
4 |
female phenotype, with posterior labial fusion, mild clitoromegaly and separate vaginal and urethral orifices |
5 |
female phenotype with pubic and axillary hair after puberty |
6 |
female phenotype with no pubic or axillary hair after puberty |
7 |
Prior to puberty a patient with a female phenotype is classified as Grade 6/7.
Specialty: Urology, Pedatrics
ICD-10: ,