Some patients with Hodgkin's Lymphoma will develop a hemophagocytic syndrome (HPS).
Features of HPS:
(1) proliferation of benign macrophages
(2) extensive phagocytosis of hematopoietic cells with cytopenias
(3) fever
(4) hepatosplenomegaly
(5) abnormal liver function tests and acute phase reaction
Typical findings in a patient with Hodgkin Lymphoma associated HPS:
(1) often male gender
(2) mixed cellularity or lymphocyte depleted Hodgkin's disease
(3) usually the presence of Epstein-Barr virus in tumor cells (100% if HIV positive, 92% if not HIV positive)
(4) disseminated Hodgkin's disease at diagnosis of HPS
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Specialty: Hematology Oncology
