The clinical and laboratory findings of a mast cell disorder are influenced by the nature of the mast cell proliferation, its total volume, its distribution and the release of cytoplasmic products such as histamine..
Constitutional findings:
(1) fatigue
(2) weight loss
(3) fever
(4) sweating
(5) flushing
Cutaneous lesions:
(1) skin lesions (macules, papules, nodules, blisters, bullae)
(1a) skin lesions may be pigmented
(1b) Darier's sign (skin lesions urticate after being stroked)
(2) pruritis
(3) dermatographism
Gastrointestinal symptoms:
(1) nausea and vomiting
(2) abdominal pain
(3) diarrhea
(4) peptic ulcer
(5) hepatomegaly
(6) splenomegaly
Musculoskeletal symptoms:
(1) bone pain
(2) muscle pain
(3) pathologic fracture
(4) arthralgias
Cardiopulmonary symptoms:
(1) tachycardia
(2) abnormal blood pressure (hypotension or hypertension)
(3) dyspnea
(4) wheezing
Neurologic symptoms:
(1) syncope
(2) headache
Hematologic findings:
(1) variable anemia
(2) variable abnormality in the WBC count (leucopenia, leukocytosis)
(3) variable abnormality in the platelet count (thrombocytopenia, thrombocytosis)
(4) eosinophilia
(5) lymphadenopathy
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Specialty: Hematology Oncology, Clinical Laboratory
ICD-10: ,
