The Churg-Strauss syndrome (allergic granulomatosis and angiitis) can be diagnosed using a classification tree approach.
|
top level |
second level |
third level |
diagnosis |
|
asthma present |
eosinophilia > 10% |
|
CSS |
|
|
eosinophilia <= 10% |
|
not CSS |
|
asthma absent |
eosinophilia > 10% |
history of allergy |
CSS |
|
|
|
no history of allergy |
not CSS |
|
|
eosinophilia <= 10% |
|
not CSS |
where:
• A history of allergy involves a history of seasonal allergy (e.g., allergic rhinitis) or other documented allergies, including food, contactants, and others, except for drug allergy.
|
Patient Subsets |
Findings |
|
CSS |
asthma and eosinophilia > 10% |
|
|
no asthma; eosinophilia > 10%; history of allergy |
|
not CSS |
no asthma; eosinophilia <= 10% |
|
|
no asthma; eosinophilia > 10%; no history of allergy |
|
|
asthma; eosinophilia <=10% |
Interpretation:
• The sensitivity of the tree classification is 95% with specificity of 99.2%.
Specialty: Immunology/Rheumatology
