Wu et al proposed a classification for primary effusion-based lymphomas (PEL). This is a modification of a classification proposed by Carbone and Gloghini. The authors are from the University of California at Irvine.
Parameters:
(1) HHV-8 status
(2) immunophenotype
(3) morphology
(4) additional testing
HHV-8
Phenotype
Morphology
Additional Testing
Diagnosis
positive
NA
NA
NA
HHV-8(+) PEL
negative
T cell
NA
NA
T cell PEL-like ENL
negative
plasma cell
NA
NA
HHV-8(-) PEL
negative
indeterminate
NA
NA
HHV-8(-) PEL
negative
B cell
Burkitt-like
c-myc rearrangement, high Ki-67 (near 100%)
Burkitt PEL-like ENL
negative
B cell
large cell
features of Burkitt's absent
large B cell PEL-like ENL
where:
• ENL = extra-nodal lymphoma
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