Acute lymphoblastic leukemia (ALL) may or may not involve the central nervous system (CNS). The extent of CNS involvement can be classified using a simple scheme.
Parameters:
(1) WBC count of the CSF
(2) lymphoblasts in the CSF
CSF WBC Count
CSF Lymphoblasts
CNS Status
NA
none
CNS-1
< 5 per µL
present
CNS-2
>= 5 per µL
present
CNS-3
where:
• The CSF WBC count can be of any value in CNS-1.
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