Criteria for Churg-Strauss syndrome is proposed at an International Consensus Conference held at the University of North Carolina, Chapel Hill, North Carolina.
Lesion: granulomatous inflammation with numerous eosinophils
Vessel
Involvement
venules
no
capillaries
no
arterioles
possible
small arteries
yes
medium-sized arteries
yes
large arteries
no
Features:
(1) asthma
(2) eosinophilia
(3) presence of pANCA
(4) no or scant immune complexes
Granulomatous inflammation with eosinophils may be seen with:
(1) Wegener's granulomatosis (cANCA positive)
(2) microscopic polyangiitis (cANCA and/or pANCA)
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