Criteria 1: organism isolated from culture of tissue or drainage from affected site
Criteria 2: purulent drainage from affected site
Criteria 3: at least one of the following:
(1) abscess or other evidence of infection seen during surgery
(2) abscess or other evidence of infection seen by histopathologic examination
Criteria 4 - both of the following:
(1) at least 2 of the following at affected site:
(1a) localized pain or tenderness (dolor)
(1b) swelling
(1c) redness (rubor)
(1d) heat (calor)
(2) at least one of the following:
(2a) organism isolated from blood culture
(2b) positive antigen test on blood or urine
(2c) diagnostic IgM antibody titer on serum for pathogen
(2d) fourfold increase in IgG antibody titer in paired serum samples for pathogen
