CDC Criteria for Endocarditis

 

Criteria 1: organism isolated from culture of heart valve or vegetation

 

Criteria 2 - all of the following:

(1) patient age > 12 months

(2) 2 or more of the following symptoms:

(2a) fever (> 38° C)

(2b) new murmur

(2c) change in murmur

(2d) embolic phenomena

(2e) skin manifestations (petechiae, splinter hemorrhages, painful subcutaneous nodules)

(2f) congestive heart failure

(2g) cardiac conduction abnormality

(3) no other recognizable cause for symptoms

(4) the physician institutes appropriate antimicrobial therapy if the diagnosis is made antemortem

(5) one or more of the following:

(5a) organism isolated from two blood cultures

(5b) organisms seen on Gram stain of valve when culture is negative

(5c) organisms seen on Gram stain of valve when culture not done

(5d) valvular vegetation seen during surgery or at autopsy

(5e) positive antigen test on blood or urine

(5f) evidence of a new vegetation seen on echocardiography

 

Criteria 3 - all of the following:

(1) patient age <= 12 months

(2) 2 or more of the following symptoms:

(2a) fever (> 38° C) or hypothermia (< 37° C)

(2b) new murmur

(2c) change in murmur

(2d) embolic phenomena

(2e) skin manifestations (petechiae, splinter hemorrhages, painful subcutaneous nodules)

(2f) congestive heart failure

(2g) cardiac conduction abnormality

(2h) apnea

(2i) bradycardia

(3) no other recognizable cause for symptoms

(4) the physician institutes appropriate antimicrobial therapy if the diagnosis is made antemortem

(5) one or more of the following

(5a) organism isolated from two blood cultures

(5b) organisms seen on Gram stain of valve when culture is negative

(5c) organisms seen on Gram stain of valve when culture not done

(5d) valvular vegetation seen during surgery or at autopsy

(5e) positive antigen test on blood or urine

(5f) evidence of a new vegetation seen on echocardiography