Park et al used a CBC score to predict prognosis of a patient with acute promyelocytic leukemia (APL). This adds hemoglobin to the 2 compenents of the PETHEMA score. The authors are from Sungkyunkwan University, Asian Medical Center, Hanlym University Hospital, Ulsan University Hospital, Catholic University Hospital, Youngnam University Hospital, and Paik Busan Hospital in Korea.
Patient selection: acute promyelocytic leukemia
Parameters:
(1) white blood cell count
(2) platelet count
(3) hemoglobin
Parameter
Finding
Points
white blood cell count
< 10,000 per µL
0
>= 10,000 per µL
1
platelet count
>= 40,000 per µL
0
< 40,000 per µL
1
hemoglobin
>= 8.0 g/dL
0
< 8.0 g/dL
1
where:
• A single hemoglobin cut-off is used rather than gender-specific ones.
CBC score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the overall survival.
CBC Score
Risk Group
5 Year Survival
0
low
90%
1
intermediate
76%
2 or 3
high
66%
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