Causes of Sideroblastic Anemia

 

Types of sideroblastic anemia:

(1) hereditary (familial)

(2) drugs and chemicals

(3) myelodysplastic (including previous chemotherapy and/or radiation)

(4) miscellaneous acquired

(5) idiopathic (if not cause found after a careful evaluation)

 

Hereditary forms may be inherited as:

(1) autosomal dominant

(2) autosomal recessive

(3) X-linked

 

Drugs and chemicals associated with sideroblastic anemia include:

(1) isoniazid

(2) ethanol abuse

(3) chloramphenicol

(4) zinc overload

(5) cycloserine

(6) penicillamine

(7) azathioprine

(8) other

 

Miscellaneous acquired causes:

(1) copper deficiency

(2) erythropoietic protoporphyria

(3) Pearson’s marrow-pancreas syndrome

(4) thiamine-responsive megaloblastic anemia

(5) hypothermia