Description

Certain conditions may interfere with the blood supply to the bile ducts, resulting in ischemic cholangiopathy.


 

Hypercoagulable state:

(1) antiphospholipid syndrome

(2) paroxysmal nocturnal hemoglobinuria (PNH)

 

Vasculitis:

(1) polyarteritis nodosa

(2) systemic lupus erythematosus

(3) Henoch-Schonlein purpura

(4) other

 

Intravascular event:

(1) cholesterol crystal embolism

(2) interventional radiology involving the hepatic artery

(3) infusion of a toxic chemical into the hepatic artery, including chemotherapeutic agents

(4) sickle cell anemia

(5) severe atherosclerosis

 

Infection related:

(1) Kawasaki disease

(2) cholangiopathy associated with septic shock

(3) AIDS-related cholangiopathy

 

Surgery-related:

(1) liver transplant

(2) postcholecystectomy stricture

 

Other:

(1) hypereosinophilia syndrome

(2) radiation field that includes the biliary system

(3) hereditary hemorrhagic telangiectasia (HHT, due to blood diverted through vascular shunts)

(4) arterial compression due to tumor or abscess

 


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