Kim et al developed a risk score for predicting risk of fatal intracranial hemorrhage (ICH) in patients with acute leukemia. This can help identify a patient who may benefit from more aggressive management. The authors are from Ulsan University in Seoul, Korea.
Parameters:
(1) gender
(2) type of acute leukemia
(3) white blood cell count
(4) platelet count
(5) prothrombin time
|
Parameter |
Finding |
Points |
|
gender |
male |
0 |
|
|
female |
1 |
|
type of acute leukemia |
acute promyelocytic |
1 |
|
|
other |
0 |
|
white blood cell count |
< 50,000 per µL |
0 |
|
|
>= 50,000 per µL |
1 |
|
platelet count |
>= 35,000 per µL |
0 |
|
|
< 35,000 per µL |
1 |
|
prothrombin time |
INR < 1.5 |
0 |
|
|
INR >= 1.5 (prolonged) |
1 |
where:
• The combination of acute promyelocytic leukemia, thrombocytopenia and prolonged PT would include those with DIC.
total risk score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the greater the risk of fatal intracranial hemorrhage.
|
Total Score |
Risk Group |
Frequency of Fatal ICH |
|
0 or 1 |
low |
< 1% |
|
2 or 3 |
intermediate |
10% |
|
4 or 5 |
high |
53% |
Purpose: To evaluate a patient with acute leukemia for the risk of fatal intracranial hemorrhage using the risk score of Kim et al.
Specialty: Hematology Oncology, Clinical Laboratory
Objective: risk factors, complication detection
ICD-10: C91, C92, C95, C91, C92, C95, C91, C92, C95, I60, I61, I62,
