Common clinical findings:
(1) systemic constitutional findings (weight loss, night sweats, fever, fatigue)
(2) anemia
(3) generalized lymphadenopathy
(4) splenomegaly and/or hepatomegaly
Variable clinical findings:
(1) cutaneous rash
(2) vasculitis
(3) neurologic changes (seizures, peripheral neuropathy, other)
(4) peripheral edema
(5) effusions
(6) TTP
(7) autoimmune hemolytic anemia
Laboratory findings:
(1) polyclonal hypergammaglobulinemia
(2) hypoalbuminemia
(3) elevated C-reactive protein (CRP)
(4) elevated IL-6 and other cytokines
(5) elevated erythrocyte sedimentation rate (ESR)
(6) herpesvirus-8 viral load (HHV-8, Kaposi-sarcoma associated herpesvirus, KSHV) in all HIV-positive patients and many HIV-negative patients
Complications:
(1) non-Hodgkin's malignant lymphoma (often plasmablastic)
(2) amyloidosis
