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CART Models of Speiser et al for a Patient with Acetaminophen-Induced Acute Liver Failure: Post-Admission Model Based on New Variables

Description

Speiser et al developed several classification and regression tree (CART) models for acetaminophen-induced acute liver failure. One is based on variables different from those of the King's College Hospital available after the hospital admission. The authors are from the United States Acute Liver Failure Study Group (ALFSG).


 

Patient selection: acetaminophen-induced acute liver failure

 

Parameters on admission (designated Day 3 to 7):

(1) coma grade I to IV

(2) serum lactate in mmol/L

(3) modified MELD

 

Coma Grade

Serum Lactate

Revised MELD

Mortality

I or II

NA

NA

35%

III or IV

< 2.5

NA

32%

III or IV

>= 2.5

< 19.6

40%

III or V

>= 2.5

>= 19.6

92%

 

Performance:

• The area under the ROC curve was 0.68 to 0.73.

 


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