Moore et al identified factors associated with vancomycin treatment failure for methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI).The authors are from Henry Ford Hospital and Wayne State University in Detroit.
Patient selection: MRSA bloodstream infection (BSI)
Parameters"
(1) APACHE 2 score
(2) MIC to vancomycin in µg/mL (using Vitek 2 method)
(3) risk group for source of infection
(4) USA300 strain of MRSA
|
Source of Infection |
Risk Group |
|
intravenous catheter |
low |
|
urinary tract |
low |
|
ear, nose or larynx |
low |
|
gynecologic |
low |
|
manipulation-related |
low |
|
osteoarticular |
intermediate |
|
soft tissue |
intermediate |
|
unknown |
intermediate |
|
endovascular |
high |
|
lower respiratory tract |
high |
|
abdominal |
high |
|
central nervous system |
high |
|
APACHE 2 |
MIC |
Risk Group |
USA300 |
Failure Rate |
|
< 14 |
<= 1 |
NA |
NA |
8% |
|
< 14 |
2 |
NA |
NA |
60% |
|
>= 14 |
NA |
low |
No |
4% |
|
>= 14 |
NA |
low |
Yes |
36% |
|
>= 14 |
NA |
not low |
NA |
46% |
Specialty: Infectious Diseases, Pharmacology, clinical
ICD-10: ,
