CART Analysis of Litvan et al for Distinguishing Progressive Supranuclear Palsy from Parkinson's Disease

Description

Litvan et al identified clinical features that can help distinguish progressive supranuclear palsy (PSP) from Parkinson's disease (PD). The authors are from NIH, Massachusetts General Hospital, Hopital de la Salpetriere (Paris), Ludwig Boltzmann Institute of Clinical Neurobiology (Vienna) and the Institute of Neurology (London).

Analysis: both logistic regression and CART performed

Parameters:

(1) benefit from levodopa therapy

(2) falls during first year

Benefit from Levodopa Therapy	Falls During First Year	Diagnosis
no	NA	PSP
yes	yes	PSP
no	no	probable PD, few PSP

Additional findings from logistic regression:

(1) tremor-dominant disease: favors Parkinson's disease

(2) unstable gait: favors PSP

(3) supranuclear vertical gaze palsy: PSP

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Description

Specialty

ICD-10