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Botulinum Toxin Injections | Comorbid Conditions That May Increase Risk of Adverse Effects

Purpose: To identify a patient who may be at increased risk for adverse effects associated with botulinum toxin therapy.

Description

Dressler and Benecke identified a number of conditions that may be associated with an increased risk for adverse effects following injections of botulinum toxin. In general botulinum toxin is associated with few serious adverse effects when used properly. The authors are from Rostock University in Germany.


 

Comorbid Condition

Comment

amyotrophic lateral sclerosis (ALS)

may worsen paresis

myopathy

may worsen paresis

motor polyneuropathy

may worsen paresis

myasthenia gravis or Lambert-Eaton syndrome (impaired neuromuscular transmission)

may worsen paresis

autonomic dysfunction

some toxin preparations (BT-B) are associated with autonomic adverse effects

anticholinergic drug therapy

some toxin preparations (BT-B) are associated with autonomic adverse effects

allergy to botulinum toxin or additives comprising the toxin preparation

serious allergic reaction such as anaphylaxis may occur

 

Comorbid Conditions with a Theoretical Risk

 

Comorbid Condition

Comment

pregnancy

no fetal problems noted in pregnancies during which toxin given by accident

concurrent therapy with an aminoglycosides antibiotic

increased paresis occurs in patients with botulism when treated with aminoglycosides

 


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Specialty

Objective

ICD-10