Harrison used the bolus test dose technique to predict the infusion rate of vecuronium needed to provide nueromuscular block. The author is from Auckland Hospital in New Zealand.
Dosing:
(1) loading dose IV (other authors mention 0.1 mg per kg, but may be 0.075 mg per kg, from page 291)
(2) 4 mg bolus administered after T1 of the train-of-four returns to 15% of control
Duration of Effect in Minutes Following Infusion of 4 mg Bolus
Infusion Rate in mg per hour
60 minutes
2.0
52 minutes
2.5
43 minutes
3.0
35 minutes
3.5
27 minutes
4.0
from Table VI, page 291.
This data is approximated in JMP as a line:
infusion rate in mg per hour =
= (-0.060215 * (duration in minutes)) + 5.6133
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