Bolus Test Dose Technique of Harrison for Predicting the Infusion Rate of Rocuronium

Description

Harrison used the test dose technique for predicting the infusion rate of rocuronium to provide neuromuscular blockage during surgery. This can reduce the guesswork in managing the individual patient. The author is from Auckland Hospital in Auckland, New Zealand.

Dosing:

(1) loading dose of 1 mg per kg IV

(2) 10 mg bolus administered after T1 of the train-of-four returns to 5% of control

Target: infusion rate to keep the T1 of the train-of-four in the range of 3-7% of the control

Duration of Effect	Infusion Rate
6 minutes	>= 60 mg per hour
8 minutes	50 mg per hour
10 minutes	40 mg per hour
15 minutes	30 mg per hour
24 minutes	20 mg per hour
34 minutes	15 mg per hour

This curve can be approximated in JMP.

Duration of Effect	Infusion Rate in mg per hour
<= 6 minutes	>= 60
6.01 to 15 minutes	(0.31217 * ((duration)^2)) - (9.931876 * (duration)) + 108.66747
15 to 33.99 minutes	(0.0321637 * ((duration)^2)) - (2.365497 * (duration)) + 58.245614
>= 34 minutes	<= 15

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Description

Specialty

ICD-10