The Biopharmaceutical Classification Scheme (BCS) classifies a drug based on its solubility and permeability characteristics.
Parameters:
(1) solubility
(2) permeability
Solubility |
Permeability |
Class |
high |
good |
1 |
low |
good |
2 |
high |
poor |
3 |
low |
poor |
4 |
where:
• One modification would be to expand the choices to include intermediate solubility and fair permeability. This would result in 9 combinations.
Class |
Potential Bioavailability After Oral Dosing |
1 |
excellent |
2 |
good to fair |
3 |
fair |
4 |
poor |
Specialty: Pharmacology, clinical